Treat & renew · Peptides
Peptides
Short chains of amino acids used in anti-aging products to support firmness and smoothness.
- Also listed as
- Matrixyl, Palmitoyl pentapeptide, Copper peptides
- Best for
- All skin types · Visible signs of aging · Sensitive skin that cannot tolerate retinoids
- When to use
- AM/PM
- Pairings
- 2 combinations checked
What it is
Peptides are building blocks of proteins like collagen. Different peptides have different jobs; some are designed to signal the skin to support collagen, others to hydrate. Evidence varies by peptide, but they are generally gentle.
Benefits
- Supports the look of firmness
- Gentle alternative or addition to retinoids
- Usually well tolerated
Watch-outs
- Results are modest and vary by formula
- Copper peptides may be best kept apart from strong acids and vitamin C
How to use it
Use morning or night after cleansing and serums, before moisturizer.
Can you mix peptides with…
- Peptides + Vitamin CUse with cautionMost peptides are fine with vitamin C, but copper peptides may be less stable next to strong acids and vitamin C.
- Peptides + RetinolWorks well togetherPeptides are gentle and do not interfere with retinol.
Frequently asked questions
What does peptides do for skin?
Short chains of amino acids used in anti-aging products to support firmness and smoothness.
Are peptides as effective as retinol?
Retinoids have stronger evidence for fine lines. Peptides are gentler and can be a good option, or an addition, for sensitive skin.
Similar ingredients
General cosmetic information, reviewed against public guidance such as the American Academy of Dermatology. Patch test new products. For medical concerns, see a dermatologist. Last updated 2026-10-22.